SSDN Innovation

Extramural Projects

Ongoing

  • To establish clinical trial networks (ctns) and strengthening hospital based trial capacity in ophthalmology (under national biopharma mission) – dr. Manabjyoti barman, senior consultant, ssn
  • A global, phase iii, double blind, randomized controlled study to compare the efficacy, safety & immunogenicity of lubt010 with lucentis® in patients with neovascular age-related macular degeneration. – pi = dr. Manabjyoti barman, icmr project, 3 years, just started)
  • Lumina: a phase iii, multicenter, sham-controlled, randomized, double-masked study assessing the efficacy and safety of intravitreal injections of 440 µg de-109 for the treatment of active, non-infectious uveitis of the posterior segment of the eye – pi – dr. Dipankar das
  • Evaluation of h2s level in vitreous, aqueous and plasma of patients suffering from diabetic retinopathy and its relation with glucose level in cells. – pi = dr. Manabjyoti barman, icmr project, 2 years, rs. 19,90,000/-
  • A double-masked, placebo controlled, randomized, phase ii clinical trial to assess the efficacy of iview – 1201 in the treatment of acute adenoviral conjunctivitis- pi = dr bal mukund agarwal, excel life science pvt. Ltd., 10 months, rs. 8,31,550/-
  • A multi-centre study of accessing childhood cancer services in india (access india study) – pi = dr manabjyoti barman
  • Translating research into clinical and community practice: a multi-centre statistical and economical modelling of risk-based stratified and personalized screening for complications of diabetes in india (smart india), vision research foundation, chennai, india – pi = dr harsha bhattacharjee, 3 years, research council uk through the mrc uk., moorfields eye hospital, london, vision research foundation, chennai, india, rs. 10,50,000/-
  • A survey of visual impairment among children in blind school in northeast india. – pi = dr damaris magdalene
  • A phase iii, multinational, multicentre, randomized, double-masked study assessing the safety and efficacy of intra-vitreal injections of de-109 (three doses) for the treatment of active, non-infectious uveitis of the posterior segment of the eye. Pi = dr. Dipankar das, excel life sciences pvt. Ltd., 2 years, rs. 1,23,180/-
  • Quark naion study qrk207: a phase 2/3, randomized, double masked, sham-controlled trial of qpi-1007 delivered by single or multi-dose intra-vitreal injection(s) to subjects with acute nonarteritic anterior ischaemic optic neuropathy (naion). Pi = dr. Dipankar das, quark pharmaceuticals, 2 years, rs. 5,27,506/-

Completed

  • Barriers and enablers for the uptake of childhood cataract services, city university london and orbis india country office. Pi = dr damaris magdalene
  • Prevalence and causes of amblyopia in children aged 6 months to 16 years in kamrup (metro) district, icmr project. Pi = dr damaris magdalene
  • Association between structural and refractive component of eye and diabetic retinopathy – srimanta sankaradeva university of health sciences. – pi = dr harsha bhattacharjee
  • Correlation of biomedical parameters hba ic and lipid profile and apo lipoprotiens in adult diabetic patients with diabetic retinopathy – srimanta sankaradeva university of health sciences. – pi = dr krishna gogoi
  • A phase iii, multinational, multicenter, randomized, double-masked, study assessing the safety and efficacy of intravitreal injections of de-109 (three doses) for the treatment of active, non-infectious uveitis of the posterior segment of the eye. – pi = dr dipankar das
  • A multicenter, controlled, safety and efficacy study of flucinolone acetonide intravitreal insert in subjects with chronic, non-infectious uveitis affecting the posterior segment of the eye. – pi = dr dipankar das
  •  Topaz: a randomized, masked, controlled trial to study the safety and efficacy of suprachoroidal cls-ta in combination with an intravitreal anti-vegf agent in subjects with retinal vein occlusion . – pi = dr ronel soibam
  • Qrk 207- a phase 2/3, randomized , double- masked, sham-controlled trial of qpi-1007 delivered by single or multi-dose intravitreal injection(s) to subjrcts with acute nonarteritic anterior ischemic neuropathy (naion) ‘ . – pi = dr dipankar das
  • Influence of media opacity due to congenital/developmental cataract on the axial length of eye. – pi = dr harsha bhattacharjee
  • Analysis of tear film parameters and conjunctival morphology before and after upper eye lid blepharoplasty. – pi = dr kasturi bhattacharjee
  • To study the effect of genetic variation in vasoactive and angiogenic factors in development of retinopathy. – pi = dr krishna gogoi
  • Early detection of organism in endophthalmitis by polymerase chain reaction (pcr) in a tertiary eye care institute in north- east india. – pi = dr krishna gogoi
  • A study on the effect of susceptible snps in htra 1 (rs 11200638) & arms 2(rs 104909240 in amd cohorts in north east region of india. – pi = dr krishna gogoi
  • Magnolia : multicenter , non interventional extension study of the safety and efficacy of cls-ta for the treatment of macular edema associated with non-infectious uveitis. – pi = dr dipankar das, excel life science pvt. Ltd., 1 year
  • Topaz: a randomized, masked, controlled trial to study the safety and efficacy of suprachoroidal cls-ta in combination with an intravitreal anti-vegf agent in subjects with retinal vein occlusion. – pi = dr ronel soibam, clearside biomedical ltd., 12 months

Intramural Projects

ONGOING

  • Pattern of granulomatous uveitis in a tertiary eye care centre. – Dr. Henal Javeri
  • Functional evaluation of corneal endothelium by combined measurement of central corneal volume and endothelial cell density following femtosecond laser assisted cataract surgery compared to conventional phacoemulsification. – Dr. Palak Chiraniya
  • Changes in corneal endothelium and central corneal thickness following trabeculectomy: a prospective interventional study in a tertiary eye care institute in North East India. – Dr. Anand Shivaji Bhosale
  • Analysis of central choroidal thickness after treatment of diabetic macular edema patient with intravitreal ranibizumab. – Dr. Nitu Kumari
  • Clinical profile of third, fourth and sixth cranial nerve palsies in patients attending a tertiary eye care centre. – Dr. Suklenmung Buragohain
  • Visual outcome of cataract surgery in uveitic eyes in a tertiary hospital in North East India. – Dr. Mohit Garg
  • Clinical profile of optic neuritis in patients attending a tertiary care centre. – Dr. Sheesham Singh
  • A comparative study of corneal endothelial cell structure and central corneal thickness between non-diabetic and diabetic patients. – Dr. Riddhi Raichura Dipak
  • Clinical profile of pre-term infants with ROP presenting to a tertiary eye hospital in North East India. – Dr. Kanika Godani
  • Prospective analysis of femtosecond laser versus manual capsulorhexis and intraocular lens decentration in white cataract. – Dr. Brenda Latsaheb
  • Clinical profile of non – arteritic anterior ischaemic optic neuropathy patients attending tertiary centre. – Dr. Saman Zameer
  • Optical coherence tomography based imaging biomarkers for visual prognosis in eyes with macular edema, secondary to retinal vein occlusion. – Dr. Anubhi Paharia
  • Prevalence and risk factors of ARMD – a randomized cross-sectional study from tertiary eye hospital in North East India. – Dr. Deb Kumar Mahato
  • Changes in tear film parameters and higher order aberrations after botulinum toxin A injection in facial dystonia. – Dr. Bhavya Gokani
  • To study the clinical profile of pachychoroid spectrum disease presenting to tertiary care centre in North East India. – Dr. Ahir Ankit Kumarpal
  • Deep learning assessment for identification of novel diagnostic and prognostic biomarkers for prediction of diabetic retinopathy in Northeast population. – Dr. Manab Jyoti Barman
  • Point-of-care-testing devices for diverse diseases from human tear biomarkers. – Dr Dipankar Das
  • ERG a reliable prognostic indicator in patient’s failing occlusion therapy. – Dr. Damaris Magdalene
  • Genetic analysis in patients with microphthalmia, anophthalmia and coloboma. – Dr. Damaris Magdalene
  • Clinical profile and surgical outcome of cataract surgery in children with persistent hyperplastic primary vitreous. – Dr. Kunal Shinde
  • Efficacy of cyclosporine monotherapy versus cyclosporine and steroid combined therapy in management of vernal keratoconjunctivitis in paediatric population. – Dr. Palak Chiraniya
  • Perspective of children’s eye health among school teachers. – Dr. Nilutparna Deori
  • Perception/awareness of eye health/common eye problems among parents in Assam(rural/urban) – Dr. Nilutparna Deori
  • Analysis of optical coherence tomography-angiography (OCT-A) changes from pre operative to post operative period in patients with idiopathic full thickness macular hole – Dr. Arijeet Roy
  • Study of relationship between some ocular biometric parameters and severity of primaryangle-closure glaucoma(PACG)- Dr.Rituparna Ghosh
  • Conventional corneal collagen cross linking versus accelerated corneal collagen cross linking in progressive keratoconus- a comparative study. – Dr. Madhusmita Mahapatra
  • Optical coherence tomography angiography (OCT-A) in chronic central serous chorioretinopathy (CSC) – Dr.Pushkar Bhadani
  • Lens parameters (lens vault, lens thickness and lens position) in primary angle closure disease. – Dr. Mitesh Jain
  • Profile of scleritis attending tertiary institute of North-East India. – Dr. Sakshi Mishra

Completed

  • Endothelial cell loss following ultrasonic phacoemulsification with in the bag IOL implant and extracapsular cataract extraction with in the bag IOL implant – a comparative study. – Dr. Debdulal Chakraborty
  • Visual performance following implantation of rigid PMMA intraocular lens and foldable acrylic intraocular lens (Acrysof) after phacoemulsification – a comparative study. – Dr. Manab Jyoti Barman
  • Incidence of glaucoma in patients with more than 0.8 cup/disc ratio – a prospective study. – Dr. Sagarmoy Purakaystha
  • Changes in endothelial cell count, optic disc topography and corneal topography following trabeculectomy. – Dr. Gitumoni Sharma
  • An ultrasound biomicroscopic study of the changes in the anterior chamber following phaco emulsification lens implantation. – Dr. Ashutosh
  • Silastic tube intubation in dacryo cystorhinostomy. – Dr. Valensha Surong
  • Clinico pathological study of limbal mass. – Dr. Pankaj Baruah
  • Management and prognosis of retinoblastoma in a tertiary eye care centre. – Dr. Hima Baruah
  • Bacterial profile of conjunctival flora & lacrimal sac flora in naso lacrimal duct obstruction – a study. – Dr. Queen Gogoi
  • Retinal thickness analysis post phacoemulsification: an optical coherence tomography based study. – Dr. Nirupam Bora
  • Intravitreal triamcinolone acetonide for diabetic macular edema. – Dr. Lopamudra Majumdar
  • A prospective study of improvement in best corrected visual acuity in amblyopic adult eyes after laser in situ keratomileusis. – Dr. Sarungbam Bobby
  • Evaluation of retinal nerve fibre layer thickness in normal, ocular hypertensive and glaucomatous eyes by using optical coherence tomography. – Dr. Mairembam Ranjana Devi
  • Correlation of lipid profile in diabetic macular edema. – Dr. Rachana Jain
  • Correlation between intra ocular pressure and central corneal thickness after laser in situ keratomileusis in eyes with myopia and myopic astigmatism. – Dr. Mrinal Mazumdar
  • Outcome analysis of therapeutic penetrating keratoplasty in microbial keratitis. – Dr. Sandeep Bora
  • Pattern of posterior uveitis in a tertiary eye care centre. – Dr. Surpriya Hawaibam
  • Outcome of phacoemulsification in chronic uveitis. – Dr. Sourav Saikia
  • Optical coherence tomography study in diabetic macular edema. – Dr. Hridayananda Pathak
  • Determinants of normal retinal nerve fiber layer thickness measured by stratus optical coherence tomography (COT) in normal hunan eyes. – Dr. Zennat Tajmin Shah
  • Analysis of changes in morphology of cornea and anterior chamber following LASIK and EPI LASIK. – Dr. Upapalli Shalomith
  • Clinical profile and management outcome of retinoblastoma in a tertiary eye care centre. – Dr. Prerana Tahiliani
  • Phacoemulsification vs. small incision cataract surgery: a randomized control trail at a tertiary eye care centre. – Dr. Akash Yadav
  • To evaluate the effects of Pascal panretinal photocoagulation on macular thickness and macular nerve fiber layer thickness in eyes with proliferative diabetic retinopathy. – Dr. Arati Diyali
  • Correlation of glycosylated haemoglobin(HbA1c) and diabetic retinopathy in patients with type-2 diabetes mellitus. – Dr. Angshuman Deka
  • Indocyanine green angiography in acute central serous chorioretinopathy. – Dr. Dina Kumar Yambem
  • Optical coherence tomography in the evaluation of anterior segment changes after phacoemuslification with IOL implantation. – Dr. Divya Pandey Marutinandan
  • Clinical profile of childhood eye diseases in a tertiary eye care centre. – Dr. Manik Das
  • Visual and clinical outcome after phakic intra ocular implantable contact lens in high myopia. – Dr. Varsha Ramachandra
  • Open globe injuries: a prospective study of patient profile and prognostic factors for visual outcome following surgical treatment at a tertiary eye care institution. – Dr. Deepika Kapoor
  • A study on fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) in clinically significant diabetic macular edema. – Dr. Rushil Kumar Saxena
  • Clinical presentation of congenital nasolacrimal duct obstruction and its outcome after conservative treatment and probing. – Dr. Serasiya Samirkumar Maganbhai
  • Study of macular retinal thickness and peripapillary retinal fiber layer thicknmess in normal, ocular hypertensive and primary open angle glaucoma patients by optical coherence tomography. – Dr. Nalinakshi Karan
  • Role of multifocal electroretinogram in diabetic retinopathy. – Dr. Akanksha Koul
  • Study of anterior chamber and irido corneal angle with anterior segment optical coherence tomography in eyes with primary angle closure disease, before and after YAG laser peripherial iridotomy. – Dr. Pawar Eknath Pandurang
  • A study to determine association of serum uric acid level with age related macular degeneration. – Dr. Patel Dhaval Ghanshyambhai
  • Analysis of contrast sensitivity, visual fields, visual aberrations and corneal topography before and after upper eyelid blepharoplasty. – Dr. Diva Kant Misra
  • Evaluation of the macula in myopic eyes by spectral domain optical coherence tomography. – Dr. Bidisha Das
  • Visual and morphological changes following collagen cross-linking treatment in keratoconus patients: a prospective study in North East India. – Dr Anusuya Bhattacharyya
  • Association of axial length of the eye with the development of diabetic retinopathy. – Dr. Prabhjot Kaur Multani
  • Anterior uveitis with HLA B27 associated spondyloarthropathy: prospective study in a tertiary institute of North-East India. – Dr. Shriya Dhar
  • Association of lattice degeneration with axial myopia: a prospective observational study at a tertiary eye care institute in North-East India. – Dr. Paulbuddhe Vivek Suryakant
  • Optical coherence tomography (OCT) assessment in macular edema in retinal vein occlusions. – Dr. Anshul Singh
  • Anterior chamber configuration changes after cataract surgery in eyes with glaucoma as measured by anterior segment OCT. – Dr. Erani Borah
  • Tear volume and ocular surface changes before and after upper lid blepharoplasty. – Dr. Nilutparnadeori
  • Clinical characteristics and microbiological profile of corneal ulcer at a tertiary eye care centre in North East India. – Dr. Gupta Krati Shivkumar
  • Clinical profile and prognostic factors for visual outcome in ocular trauma patients presenting to a tertiary eye care center in North-East India. – Dr. Saurabh Deshmukh
  • Evaluation of the surgical outcome following minimally invasive pterygium excision surgery. – Dr. Sumegha Singh Tomar
  • Evaluation of pre-corneal tear film status in diabetic and non-diabetic patients in a tertiary eye care centre in Northeast India. – Dr. Pranjal Mishra
  • Correlation of optical coherence tomography and electroretinography findings in patients with diabetic macular edema treated with ranibizumab. – Dr. Rama Mohanarao Paidi
  • Association of serum bilirubin levels with development and severity of diabetic retinopathy in type 2 diabetes mellitus. – Dr. Puneet Misra
  • Macular thickness changes after glaucoma filtration surgery. – Dr. Bhavya Mehta
  • Correlation between spectral domain optical coherence tomography findings and visual outcome after repair of rhegmatogenous retinal detachment with macula-off. – Dr. Fazil Khurrum
  • Profile of retinal vasculitis attending tertiary centre of North-East India. – Dr. Priyank Bhola
  • Comparison of the surgical outcomes of sutureless pterygium surgery with conjunctival autograft using fibrin glue versus autologous blood at a tertiary eye care centre in North-East India. – Dr. Mandabi Sengupta
  • Study of choroid thickness and its association with primary angle closure disease. – Dr. Tanvi Gupta
  • Corneal thickness and curvature changes following collagen crosslinking treatment for keratoconus. – Dr. Shyam Sundar Das Mohapatra
  • Analysis of corneal stromal and corneal nerve changes following LASIK using in vivo confocal microscopy (VCM). – Dr. Isha Agarwalla
  • Endothelial cell loss in diabetic and non-diabetic eyes after phacoemulsification surgery: a comparative study. – Dr. Pooja Gupta
  • Comparative analysis of visual acuity & inner segment-outer segment photoreceptor disruption in diabetic macular edema before & after intravitreal anti-VEGF therapy. – Dr. Meenakshi Sharma
  • Retinal and choroidal thickness after femtosecond laser assisted cataract surgery and standard phacoemulsification. – Dr. Prakhar Chaudhary
  • Study of macular ganglion cell complex thickness and peripapillary retinal nerve fibre layer thickness in the assessment of early glaucoma. – Dr. Shashank Agarwal
  • Effect of laser peripheral iridotomy on corneal endothelial cell density and cell morphology in primary angle closure suspect. – Dr Tejpal Patel
  • Profile of intermediate uveitis in a tertiary eye care centre. – Dr. Amit Kumar
  • Spectral domain optical coherence tomography based biomarkers for visual prognosis in eyes with centre -involving diabetic macular edema. – Dr. Kunal Shinde